Molecular Diagnostics

The examination in Molecular Diagnostics tests the candidate’s Recall and Applied skills and is comprised of one part.


The examination tests mastery and knowledge of 1) genetics, 2) molecular biology, 3) hematology, 4) microbiology, 5) identity/HLA, 6) pharmacogenetics/biomarkers, 7) solid tumors, 8) techniques, and 9) management.

All questions are in multiple-choice format with one correct answer of options A-E. The molecular diagnostics examination has an average cumulative 5-year pass rate of 31%.

Molecular Diagnostics Exam (3 hours)

For Part A, the examinee is expected to perform calculations and problem solving related to:

  • Principles
  • Concepts
  • Methodologies
  • Usage of molecular biology technique as applied to clinical chemistry

Suggested Study Resources

Past examinees have identified the following activities as beneficial for preparing for this examination. These activities are NOT meant to be comprehensive guides but rather are presented to illustrate the broad nature of clinical molecular diagnostics. They are not endorsed by the ABCC.


  • Diagnostic Molecular Pathology in Practice: A Case-Based Approach. Iris Schrijver (Editor). Springer, New York, NY.
  • Human Genetics and Genomics. Bruce R Korf and Mira B Irons. Wiley-Blackwell, Hoboken, NJ.
  • Molecular Diagnostics: For the Clinical Laboratorian. William B Coleman and Gregory J Tsongalis (Editors). Humana Press, New York, NY.
  • Molecular Pathology in Clinical Practice. Debra GB Leonard (Editor). Springer, New York, NY.
  • Thompson & Thompson’s Genetics in Medicine. Robert Nussbaum, Roderick R McInnes and, Huntington F Willard (Editors). WB Saunders, Philadelphia, PA.
  • Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Carl A Burtis, Edward R Ashwood, and David E Bruns (Editors), WB Saunders, Saint Louis, MO.